1.
J Infect Dis
; 224(3): 559-561, 2021 08 02.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1371734
2.
J Infect Dis
; 222(7): 1103-1107, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: covidwho-663915
RESUMEN
The antiviral drug remdesivir has been shown clinically effective for treatment of COVID-19. We here demonstrate suppressive but not curative effect of remdesivir in an immunocompromised patient. A man in his fifties treated with chemoimmunotherapy for chronic lymphocytic leukemia experienced a 9-week course of COVID-19 with high fever and severe viral pneumonia. During two 10-day courses of remdesivir starting 24 and 45 days after fever onset, pneumonia and spiking fevers remitted, but relapsed after discontinuation. Kinetics of temperature, C-reactive protein, and lymphocyte counts mirrored the remitting/relapsing SARS-CoV-2 infection. Combination therapy or longer treatment duration may be needed in immunocompromised patients.